SYNOVIAL FIBROBLAST SIALYLATION REGULATES CELL MIGRATION AND ACTIVATION OF INFLAMMATORY PATHWAYS IN ARTHRITOGENESIS

Synovial Fibroblast Sialylation Regulates Cell Migration and Activation of Inflammatory Pathways in Arthritogenesis

Synovial fibroblasts have emerged as critical underlying factors to perpetuate chronic joint inflammation in Rheumatoid Arthritis.Like any other cell, synovial fibroblasts are covered with a complex layer of glycans that can change in response to extracellular signals, such as inflammation.We have Chargers previously shown that inflammatory synovia

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AUCReshaping: improved sensitivity at high-specificity

Abstract The evaluation of deep-learning (DL) systems typically relies on the Area under the Receiver-Operating-Curve (AU-ROC) as a performance metric.However, AU-ROC, in its holistic form, does not sufficiently consider performance within specific ranges of sensitivity and specificity, which are critical for the intended operational context of the

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Multiscale Entropy Analysis of Instantaneous Frequency Variation to Overcome the Cross-Over Artifact in Rhythmic EEG

Generally, for healthy adults, the entropy of electroencephalogram (EEG) signals gradually decreases from wake to sleep stages N1, N2, to N3, and increases during REM.However, some researchers found that multiscale entropy curves of sleep and wakefulness intercept, a cross-over phenomenon whose origin remains unexplored.The objective of the present

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